Hormonal regulators of adipose tissue plasticity
About the Project
The Collaborative Research Centre 1052 “Obesity Mechanisms” was established in 2013 with funding from the German Research Foundation (DFG). The doctoral researcher position is limited to 3 years. The salary is paid according to the German TV-L system (the salary agreement for public service employees).
Supervisor: Dr. Kerstin Krause
The Collaborative Research Center 1052 “Obesity Mechanisms” was established in 2013 with funding from the German Research Foundation (DFG). The CRC1052 combines interdisciplinary basic and clinical research across biochemistry, biophysics and chemistry, endocrinology, neuroscience, paediatrics, and cardiology. It aims to provide structured doctoral training centrally aligned in three main research areas – A, Overeating, B, Fat deposition and inflammation, and C, Adipokines. With the successful extension for a 3rd funding period to 2024, we are looking for highly motivated candidates to study the complex and multifactorial disorder mechanisms of obesity.
Aim of the PhD project:
This project (CRC/B12) will elaborate on the adipose depot-specific activation of adipocyte precursors in response to thyroid hormone signaling. We will delineate the multidirectional crosstalk between thyroid hormones, sympathetic nervous system, adipokines and the thermogenic response in brown and beige adipocytes and related effects on energy balance. Furthermore we aim to delineate pathways in the adipocyte that mediate the effects of thyroid hormones on thermogenesis in white and brown fat. This project will include innovative imaging methods for quantification of brown fat activity, cell biology, molecular biology and animal experiments in mice. The PhD position (TV-L, E13, 65%) is available from 01.01.2022 for 3 years. The applicant should have a Master’s degree in Biochemistry, Molecular Life Science or similar. The successful candidate should be enthusiastic and provide a strong research interest in endocrinology and obesity. The PhD student will be integrated in the Integrated Research Training Group at the CRC1052.
How to apply:
For further information, please contact Dr. Kerstin Krause,firstname.lastname@example.org. To apply for the positions applicants should complete the Application form and include a full academic CV, publication list (if any), copies of your degree certificates and contact details of two referees.
The applications will be accepted until 15th of September via e-mail to the CRC office email@example.com
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